工作学习经历

2021.12-至今 湘潭大学化学学院教授，博士生导师

2016.12-2021.12 湘潭大学化学学院 副教授

2015.1-2017.1 香港浸会大学 香江学者

2012.12-2016.10 湖南大学化学化工学院 讲师

2009.9-2012.12 湖南大学化学化工学院 博士研究生

主讲课程

《仪器分析》、《现代仪器分析》、《分析化学实验》

研究方向

功能分子探针设计、合成及化学生物传感

主要学术成果

一、 近年来发表的部分学术论文(通讯作者或第一作者)

1. Engineering trienzyme cascade-triggered fluorescent immunosensor platform by sequentially integrating alkaline phosphatase, tyrosinase and horseradish peroxidase. Chinese Chemical Letters, 2023, 34, 107654.

2. A New Ratiometric Design Strategy Based on Modulation of π-Conjugation Unit for Developing Fluorescent Probe and Imaging of Cellular Peroxynitrite. Analytical Chemistry, 2022, 94, 4763-4769.

3. Development of Probes with High Signal-to-Noise Ratios Based on the Facile Modification of Xanthene Dyes for Imaging Peroxynitrite during the Liver Ischemia/Reperfusion Process. Analytical Chemistry, 2022, 94, 10773-10780.

4. Rational Design of Novel Lipophilic Aggregation-Induced Emission Probes for Revealing the Dynamics of Lipid Droplets during Lipophagy and Ferroptosis. Analytical Chemistry, 2022, 94, 13432-13439.

5. A novel near-infrared viscosity probe based on synergistic effect of AIE property and molecular rotors for mitophagy imaging during liver injury. Analytica Chimica Acta, 2021, 1187, 339146.

6. Multimodal Theranostic Cyanine Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid‑β in an Alzheimer’s Disease Mouse Model. ACS Appl. Mater. Interfaces, 2021, 13, 18525-18532.

7. Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy. Trends in Analytical Chemistry, 2020, 131, 116010.

8. Versatile fluorescent probes for near-infrared imaging of amyloid-b species in Alzheimer’s disease mouse model. J. Mater. Chem. B, 2019, 7, 1986-1995.

9. Dual-Modal NIR-Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid β Species In Vivo. Small, 2018, 14, 201800901.

10. A Zero Cross-Talk Ratiometric Two-Photon Probe for Imaging of Acid pH in Living Cells and Tissues and Early Detection of Tumor in Mouse Model. Analytical Chemistry, 2018, 90, 8800-8806.

11. A two-photon ratiometric fluorescent probe for effective monitoring of lysosomal pH in live cells and cancer tissues. Sensors and Actuators B: Chemical, 2018, 262, 913-921.

12. Fluoro-Substituted Cyanine for Reliable in vivo Labelling of Amyloid-β Oligomers and Neuroprotection against Amyloid-β Induced Toxicity. Chemical Science, 2017, 8, 8279-8284.

13. Engineering a Nanolab for the Determination of Lysosomal Nitric Oxide by Rational Design of a pH-activatable Fluorescent Probe. Chemical Science, 2016, 7, 1920-1925.

14. Highly Selective Two-Photon Fluorescent Probe for Ratiometric Sensing and Imaging Cysteine in Mitochondria. Analytical Chemistry, 2016, 88, 1908-1914.

15. A Theranostic Agent for in Vivo Near-Infrared Imaging of β-Amyloid Species and Inhibition of β-Amyloid Aggregation. Biomaterials, 2016, 94, 84-92.

16. Fabrication of an Electrochemical Sensor Based on Spiropyran for Sensitive and Selective Detection of Fluoride Ion. Analytica Chimica Acta, 2016, 918, 97-102.

17. Selective Tracking of Lysosomal Cu2+ Ions Using Simultaneous Target- and Location Activated Fluorescent Nanoprobe. Analytical Chemistry, 2015, 87, 584-591.

18. Hemicyanine-based High Resolution Ratiometric near-Infrared Fluorescent Probe for Monitoring pH Changes in Vivo. Analytical Chemistry, 2015, 87, 2495-2503.

19. Sensitive and Rapid Detection of Endogenous Hydrogen Sulfide Distributing in Different Mouse Viscera via a Two-photon Fluorescent Probe. Analytica Chimica Acta, 2015, 896, 128-136.

20. Development of Spiropyran-based Electrochemical Sensor via Simultaneous Photochemical and Target-Activatable Electron Transfer. Biosensors and Bioelectronics, 2014, 62, 151-157.

21. Self-assembly of Graphene Oxide with Silylated Dye for Rapid and Sensitive Colorimetric Detection of Fluoride Ions in Aqueous Solution. Analytical Chemistry, 2013. 85, 11456-11463.

22. Simultaneous Nucleophilic-Substituted and Electrostatic Interactions for Thermal Switching of Spiropyran: A New Approach for Rapid and Selective Colorimetric Detection of Thiol-Containing Amino Acids. Analytical Chemistry, 2012, 84, 4732-4738.

23. Simultaneous Intracellular β-D-Glucosidase and Phosphodiesterase I Activities Measurement Based on A Triple-Signaling Fluorescent Probe. Analytical Chemistry, 2011, 83, 1268-1274.

二、主持科研项目：

1. 国家自然科学基金面上项目，21974119，“基于AD早期诊断的Aβ寡聚体探针设计及NIRF-MRI双模态成像研究”，2020.1-2023.12。

2. 国家自然科学基金青年基金，21305036，“基于螺吡喃结构互变的比率型双光子探针设计及肝脏中碱性磷酸酶表达水平分析”，2014.1-2016.12。

3. 湖湘青年英才项目，2020RC3046，2021.1-2023.12。

4. 湖南省科技创新计划项目，2017XK2048，“长株潭***人才聚集工程”，2017.1-2019.12。

5. 湖南省自然科学基金“优秀青年基金”，2019JJ30020， “功能分子探针的设计与成像研究”，2019.1-2021.12。

6. 湖南省教育厅重点项目，22A0105，“基于AD氧化应激水平监测的荧光探针设计及成像分析”, 2022.9-2025.12。

7. 湖南省自然科学基金青年基金，2015JJ3035，“比率型双光子传感平台的构建及其在生物成像中的应用研究”，2015.1-2017.12。

8. 中国博士后科学基金第58批面上项目一等资助，2015M580685，2015.10-2017.1。

9. 湖南大学化学生物传感与计量学国家重点实验室开放课题，2017005，2018.4-2020.3。

10. 湘潭大学学术带头人科研启动项目。

个人简介

李银辉，教授，博士生导师，主要从事分子探针的开发与化学生物传感应用研究。2012年10月博士毕业于湖南大学分析化学专业，同年留校工作。2014年，入选“香江学者计划”，2015年1月至2017年1月于香港浸会大学开展研究工作。2016年10月入职湘潭大学。2017年入选“长株潭***人才聚集工程”，2020年入选“湖湘青年英才”。先后主持国家自然科学基金面上项目/青年项目、湖南省自然科学基金“优秀青年”项目、湖南省教育厅重点项目等十余项科研项目，以第一作者或通讯作者在Chemical Science、Analytical Chemistry、Small、Biomaterials等国际高水平期刊上发表SCI论文三十余篇。2019年度和2020年度分别获得年湖南省自然科学奖一等奖(排名第五)、湖南省自然科学奖二等奖(排名第二)。